3D OCT imaging in clinical settings: toward quantitative measurements of retinal structures

Robert J. Zawadzki; Alfred R. Fuller; Mingtao Zhao; David F. Wiley; Stacey S. Choi; Bradley A. Bower; Bernd Hamann; Joseph A. Izatt; John S. Werner

doi:10.1117/12.647567

7 March 2006 3D OCT imaging in clinical settings: toward quantitative measurements of retinal structures

Robert J. Zawadzki, Alfred R. Fuller, Mingtao Zhao, David F. Wiley, Stacey S. Choi, Bradley A. Bower, Bernd Hamann, Joseph A. Izatt, John S. Werner

Author Affiliations +

Proceedings Volume 6138, Ophthalmic Technologies XVI; 613803 (2006) https://doi.org/10.1117/12.647567
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

The acquisition speed of current FD-OCT (Fourier Domain - Optical Coherence Tomography) instruments allows rapid screening of three-dimensional (3D) volumes of human retinas in clinical settings. To take advantage of this ability requires software used by physicians to be capable of displaying and accessing volumetric data as well as supporting post processing in order to access important quantitative information such as thickness maps and segmented volumes. We describe our clinical FD-OCT system used to acquire 3D data from the human retina over the macula and optic nerve head. B-scans are registered to remove motion artifacts and post-processed with customized 3D visualization and analysis software. Our analysis software includes standard 3D visualization techniques along with a machine learning support vector machine (SVM) algorithm that allows a user to semi-automatically segment different retinal structures and layers. Our program makes possible measurements of the retinal layer thickness as well as volumes of structures of interest, despite the presence of noise and structural deformations associated with retinal pathology. Our software has been tested successfully in clinical settings for its efficacy in assessing 3D retinal structures in healthy as well as diseased cases. Our tool facilitates diagnosis and treatment monitoring of retinal diseases.

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Robert J. Zawadzki, Alfred R. Fuller, Mingtao Zhao, David F. Wiley, Stacey S. Choi, Bradley A. Bower, Bernd Hamann, Joseph A. Izatt, and John S. Werner "3D OCT imaging in clinical settings: toward quantitative measurements of retinal structures", Proc. SPIE 6138, Ophthalmic Technologies XVI, 613803 (7 March 2006); https://doi.org/10.1117/12.647567

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