Utility of tumor-avid photosensitizers in developing bifunctional agents for tumor imaging and/or phototherapy

Suresh K. Pandey; Yihui Chen; Robert H. Zawada; Allan Oseroff; Ravindra K. Pandey

doi:10.1117/12.647866

6 March 2006 Utility of tumor-avid photosensitizers in developing bifunctional agents for tumor imaging and/or phototherapy

Suresh K. Pandey, Yihui Chen, Robert H. Zawada, Allan Oseroff, Ravindra K. Pandey

Author Affiliations +

Proceedings Volume 6139, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV; 613905 (2006) https://doi.org/10.1117/12.647866
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

HPPH (a chlorophyll-a analog) was linked with a cyanine dye and the resulting conjugate was found to be an efficient tumor imaging (fluorescence imaging) and photosensitizing agent (PDT). Our preliminary results suggest that tumor-avid porphyrin-based compounds can be used as vehicles for delivering the desired fluorophores to tumor for fluorescence imaging. In an early diagnosis of microscopic lesions in pre-clinical studies (C3H mice implanted with RIF tumors) the HPPH-cyanine dye conjugate showed tumor-imaging capability (λ_ex: 780 nm, λ_em: 860 nm) at the non- therapeutic doses that are 100 fold lower than those used therapeutically. Compared to the cyanine dye, the corresponding HPPH-conjugate showed enhanced long-term tumor imaging ability.

Citation Download Citation

Suresh K. Pandey, Yihui Chen, Robert H. Zawada, Allan Oseroff, and Ravindra K. Pandey "Utility of tumor-avid photosensitizers in developing bifunctional agents for tumor imaging and/or phototherapy", Proc. SPIE 6139, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV, 613905 (6 March 2006); https://doi.org/10.1117/12.647866

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