Optical spectroscopy by 5-aminolevulinic acid hexylester induced photodynamic treatment in rat bladder cancer

Eivind L. P. Larsen; Lise L. Randeberg; Odrun A. Gederaas; Carl-Jørgen Arum; Hans E. Krokan; Dag R. Hjelme; Lars O. Svaasand

doi:10.1117/12.646463

6 March 2006 Optical spectroscopy by 5-aminolevulinic acid hexylester induced photodynamic treatment in rat bladder cancer

Eivind L. P. Larsen, Lise L. Randeberg, Odrun A. Gederaas, Carl-Jørgen Arum, Hans E. Krokan, Dag R. Hjelme, Lars O. Svaasand

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Proceedings Volume 6139, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV; 61390C (2006) https://doi.org/10.1117/12.646463
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Photodynamic therapy (PDT) is a treatment modality which has been shown to be effective for both malignant and non-malignant diseases. New photosensitizers such as 5-aminolevulinic acid hexylester (hALA) may increase the efficiency of PDT. Monitoring of the tissue response provides important information for optimizing factors such as drug and light dose for this treatment modality. Optical spectroscopy may be suited for this task. To test the efficacy of hALA induced PDT, a study on rats with a superficial bladder cancer model, in which a bladder cancer cell line (AY-27) is instilled, will be performed. Preliminary studies have included a PDT feasibility study on rats, fluorescence spectroscopy on AY-27 cell suspensions, and optical reflection and fluorescence spectroscopy in rat bladders in vivo. The results from the preliminary studies are promising, and the study on hALA induced PDT treatment of bladder cancer will be continued.

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Eivind L. P. Larsen, Lise L. Randeberg, Odrun A. Gederaas, Carl-Jørgen Arum, Hans E. Krokan, Dag R. Hjelme, and Lars O. Svaasand "Optical spectroscopy by 5-aminolevulinic acid hexylester induced photodynamic treatment in rat bladder cancer", Proc. SPIE 6139, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV, 61390C (6 March 2006); https://doi.org/10.1117/12.646463

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KEYWORDS

Bladder

Photodynamic therapy

Bladder cancer

Luminescence

In vivo imaging

Fluorescence spectroscopy

Optical spectroscopy

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