Myocardial physiology measurements using contrast enhanced dynamic computed tomography: simulation of beam hardening effect

Minsong Cao; Keith M. Stantz; Yun Liang

doi:10.1117/12.654206

13 March 2006 Myocardial physiology measurements using contrast enhanced dynamic computed tomography: simulation of beam hardening effect

Minsong Cao, Keith M. Stantz, Yun Liang

Author Affiliations +

Proceedings Volume 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images; 61432N (2006) https://doi.org/10.1117/12.654206
Event: Medical Imaging, 2006, San Diego, California, United States

Abstract

Initial animal study for quantifying myocardial physiology through contrast-enhanced dynamic x-ray CT suggested that beam hardening is one of the limiting factors for accurate regional physiology measurement. In this study, a series of simulations were performed to investigate its deterioration effects and two correction algorithms were adapted to evaluate for their efficiency in improving the measurements. The simulation tool consists of a module simulating data acquisition of a real polyenergetic scanner system and a heart phantom consisting of simple geometric objects representing ventricles and myocardium. Each phantom component was modeled with time-varying attenuation coefficients determined by ideal iodine contrast dynamic curves obtained from experimental data or simulation. A compartment model was used to generate the ideal myocardium contrast curve using physiological parameters consistent with measured values. Projection data of the phantom were simulated and reconstructed to produce a sequence of simulated CT images. Simulated contrast dynamic curves were fitted to the compartmental model and the resultant physiological parameters were compared with ideal values to estimate the errors induced by beam hardening artifacts. The simulations yielded similar deterioration patterns of contrast dynamic curves as observed in the initial study. Significant underestimation of left ventricle curves and corruption of regional myocardium curves result in systematic errors of regional perfusion up to approximately 24% and overestimates of fractional blood volume (f_iv) up to 13%. The correction algorithms lead to significant improvement with errors of perfusion reduced to 7% and errors of f_iv within 2% which shows promise for more robust myocardial physiology measurement.

Citation Download Citation

Minsong Cao, Keith M. Stantz, and Yun Liang "Myocardial physiology measurements using contrast enhanced dynamic computed tomography: simulation of beam hardening effect", Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 61432N (13 March 2006); https://doi.org/10.1117/12.654206

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
9 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Physiology

Computer simulations

Heart

Iodine

Error analysis

X-ray computed tomography

X-rays

Show All Keywords

Keywords/Phrases

Search In:

Publication Years