A voxel-based partial volume correction in nuclear medicine

Hsuan-Ming Huang; Ing-Tsung Hsiao; Christian Wietholt; Ching-Han Hsu

doi:10.1117/12.654273

20 March 2006 A voxel-based partial volume correction in nuclear medicine

Hsuan-Ming Huang, Ing-Tsung Hsiao, Christian Wietholt, Ching-Han Hsu

Proceedings Volume 6144, Medical Imaging 2006: Image Processing; 61446P (2006) https://doi.org/10.1117/12.654273
Event: Medical Imaging, 2006, San Diego, California, United States

Abstract

Most partial volume correction (PVC) methods are ROI-based, and assume uniform activity within each ROI. Here, we extended a PVC method, developed by Rousset et al (JNM, 1998) called geometric transfer matrix (GTM), to a voxel-based PVC approach called v-GTM which accounts non-uniform activity within each ROI. The v-GTM method was evaluated using simulated data (perfect co-registered MRIs). We investigated the influence of noise, the effect of compensating detector response during iterative reconstruction methods and the effect of non-uniform activity. For simulated data, noise did not affect the accuracy of v-GTM method seriously. When detector response compensation was applied in iterative reconstruction, both PVC methods did not improve the recovery values. In the non-uniform experiment, v-GTM had slightly better recovery values and less bias than those of GTM. Conclusion: v-GTM resulted better recovery values, and might be useful for PVC in small regions of interest.

Citation Download Citation

Hsuan-Ming Huang, Ing-Tsung Hsiao, Christian Wietholt, and Ching-Han Hsu "A voxel-based partial volume correction in nuclear medicine", Proc. SPIE 6144, Medical Imaging 2006: Image Processing, 61446P (20 March 2006); https://doi.org/10.1117/12.654273

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