Plasma lipids profile and erythrocytes system in patients with coronary heart disease

Lidia I. Malinova; Georgy V. Simonenko; Valery V. Tuchin; Tatyana P. Denisova

doi:10.1117/12.697422

24 July 2006 Plasma lipids profile and erythrocytes system in patients with coronary heart disease

Lidia I. Malinova, Georgy V. Simonenko, Valery V. Tuchin, Tatyana P. Denisova

Proceedings Volume 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII; 61631O (2006) https://doi.org/10.1117/12.697422
Event: Saratov Fall Meeting 2005, 2005, Saratov, Russian Federation

Abstract

Erythrocytes system study can provide a framework for detailed exploration of blood cell-cell and cell-vessel wall interactions, one of the key patterns in blood and vascular pathophysiology. Our objective was to explore erythrocytes system in patients with stable angina pectoris II f.c. (Canadian classification). The participants (N = 56, age 40 - 55 years) without obesity, glucose tolerance violations, lipid lowering drugs treating, heart failure of II and more functional classes (NYHA), coronary episode at least 6 months before study were involved in the study. Blood samples were incubated with glucose solutions of increasing concentrations (from 2.5% to 20% with 2.5% step) during 60 mm (36° C). In prepared blood smears erythrocyte's sizes were studied. Plasma total cholesterol, triglyceride and glucose levels were also measured. Received data were approximated by polynomials of high degree, with after going first and second derivations. Erythrocytes system "behavior" was studied by means of phase pattern constructing. By lipids levels all the patient were divided into five groups: 1) patients with normal lipids levels, 2) patients with borderline total cholesterol level, 3) patients with isolated hypercholesterolemia, 4) patients with isolated hypertriglyceridemia and 5) patients with combined hyperlipidemia. Erythrocytes size lowering process was of set of "stages", which characteristics differ significantly (p > 0.05) in all five groups. Their rate and acceleration characteristics allow us to detect type of lipid profile in patients. Erythrocyte system disturbing by glucose concentration increase show to be most resistant in group of patients with isolated hypercholesterolemia.

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Lidia I. Malinova, Georgy V. Simonenko, Valery V. Tuchin, and Tatyana P. Denisova "Plasma lipids profile and erythrocytes system in patients with coronary heart disease", Proc. SPIE 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII, 61631O (24 July 2006); https://doi.org/10.1117/12.697422

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KEYWORDS

Glucose

Blood

Heart

Plasma

Statistical analysis

Blood circulation

Classification systems

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