Characterization of malaria infected blood cells by scanning confocal laser and acoustic vector contrast microscopy

E. T. Ahmed Mohamed; S. Schubert; T. W. Gilberger; A. Kamanyi Jr.; R. Wannemacher; W. Grill

doi:10.1117/12.657892

15 March 2006 Characterization of malaria infected blood cells by scanning confocal laser and acoustic vector contrast microscopy

E. T. Ahmed Mohamed, S. Schubert, T. W. Gilberger, A. Kamanyi Jr., R. Wannemacher, W. Grill

Author Affiliations +

Proceedings Volume 6177, Health Monitoring and Smart Nondestructive Evaluation of Structural and Biological Systems V; 617716 (2006) https://doi.org/10.1117/12.657892
Event: Nondestructive Evaluation for Health Monitoring and Diagnostics, 2006, San Diego, CA, United States

Abstract

Acoustic and optical multiple contrast microscopy has been employed in order to explore characterizable parameters of red blood cells, including cells infected by the parasite Plasmodium falciparum, in order to investigate cellular modifications caused by the infection and to identify possible detection schemes for disease monitoring. Imaging schemes were based on fluorescence, optical transmission, optical reflection, and amplitude and phase of ultrasound reflected from the cells. Contrast variations observed in acoustic microscopy, but not in optical microscopy, were tentatively ascribed to changes caused by the infection.

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E. T. Ahmed Mohamed, S. Schubert, T. W. Gilberger, A. Kamanyi Jr., R. Wannemacher, and W. Grill "Characterization of malaria infected blood cells by scanning confocal laser and acoustic vector contrast microscopy", Proc. SPIE 6177, Health Monitoring and Smart Nondestructive Evaluation of Structural and Biological Systems V, 617716 (15 March 2006); https://doi.org/10.1117/12.657892

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KEYWORDS

Acoustics

Confocal microscopy

Microscopy

Blood

Ultrasonography

Luminescence

Optical microscopy

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