Liquid core optical ring resonator label-free biosensor array for lab-on-a-chip development

Ian M. White; Hongying Zhu; Jonathan D. Suter; Hesam Oveys; Xudong Fan

doi:10.1117/12.684816

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25 October 2006 Liquid core optical ring resonator label-free biosensor array for lab-on-a-chip development

Ian M. White, Hongying Zhu, Jonathan D. Suter, Hesam Oveys, Xudong Fan

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Proceedings Volume 6380, Smart Medical and Biomedical Sensor Technology IV; 63800F (2006) https://doi.org/10.1117/12.684816
Event: Optics East 2006, 2006, Boston, Massachusetts, United States

Abstract

Label-free optical biosensors offer advantages for many applications due to their simplicity and low cost compared to fluorescence detection. Thus, it is desirable to develop label-free sensors that can be integrated with advanced microfluidic systems into dense, multi-purpose biosensor arrays. One candidate technology is ring resonators, which utilize the resonating whispering gallery modes to create a strongly enhanced optical field in the sensing volume. Because of the high Q-factor of ring resonators, the optical field can be enhanced by 2-3 orders of magnitude, which leads to much smaller required light-matter interaction length and sensing volume. These are critical characteristics for dense integration into lab-on-a-chip systems. We have developed a novel label-free ring resonator sensor based on a liquid core optical ring resonator (LCORR). This system uses a glass capillary as both the fluidics and the ring resonator. With the LCORR, we have demonstrated a measurable whispering gallery mode spectral shift of 30 pm/refractive-index-unit (RIU), which leads to a detection limit of approximately 10^-6 RIU. Additionally, we have achieved an estimated detection limit for protein molecules of 10 pg/mm². These experimental demonstrations of this novel sensing system will lead to the development of highly sensitive label-free sensors that are well-suited for dense integration with advanced microfluidics for lab-on-a-chip systems.

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Ian M. White, Hongying Zhu, Jonathan D. Suter, Hesam Oveys, and Xudong Fan "Liquid core optical ring resonator label-free biosensor array for lab-on-a-chip development", Proc. SPIE 6380, Smart Medical and Biomedical Sensor Technology IV, 63800F (25 October 2006); https://doi.org/10.1117/12.684816

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