Molecular imaging of hemoglobin using ground state recovery pump-probe optical coherence tomography

Brian E. Applegate; Joseph A. Izatt

doi:10.1117/12.703272

7 February 2007 Molecular imaging of hemoglobin using ground state recovery pump-probe optical coherence tomography

Brian E. Applegate, Joseph A. Izatt

Proceedings Volume 6429, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI; 64291Y (2007) https://doi.org/10.1117/12.703272
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

We have undertaken an effort to further develop ground state recovery Pump-Probe Optical Coherence Tomograpy (gsrPPOCT) to specifically target and measure 3-D images of hemoglobin concentration with the goals of mapping tissue vasculature, total hemoglobin, and hemoglobin oxygen saturation. As a first step toward those goals we have measured the gsrPPOCT signal from the hemoglobin in the filament arteries of a zebra danio fish. We have further processed the resulting signal to extract a qualitative map of the hemoglobin concentration. We have also demonstrated the potential to use ground state recovery times to differentiate between two chromophores which may prove to be an effective tool for differentiating between oxy and deoxy hemoglobin.

Citation Download Citation

Brian E. Applegate and Joseph A. Izatt "Molecular imaging of hemoglobin using ground state recovery pump-probe optical coherence tomography", Proc. SPIE 6429, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI, 64291Y (7 February 2007); https://doi.org/10.1117/12.703272

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