Prior information in fluorescence molecular tomography based on multispectral fluorescence emission

J. Axelsson; J. Svensson; S. Andersson-Engels

doi:10.1117/12.699464

13 February 2007 Prior information in fluorescence molecular tomography based on multispectral fluorescence emission

J. Axelsson, J. Svensson, S. Andersson-Engels

Proceedings Volume 6434, Optical Tomography and Spectroscopy of Tissue VII; 64340D (2007) https://doi.org/10.1117/12.699464
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Fluorescence molecular tomography (FMT) suffers from inherent ill-posedness due to the vast number of possible solutions to the reconstruction problem. To increase the robustness of such a problem one need prior information. We present here a method for rendering a priori information of the position of a fluorescent inclusion inside turbid media. The method utilizes solely two spectral bands within the fluorescence spectrum emitted from the fluorophore. The method is presented and verified using experimental data from a tissue phantom. The confinement is also used to impose weights onto the voxels before the inversion of the linear set of equations describing the FMT problem.

Citation Download Citation

J. Axelsson, J. Svensson, and S. Andersson-Engels "Prior information in fluorescence molecular tomography based on multispectral fluorescence emission", Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 64340D (13 February 2007); https://doi.org/10.1117/12.699464

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