Development of broadband multi-channel NIRS (near-infrared spectroscopy) imaging system for quantification of spatial distribution of hemoglobin derivatives

Dheerendra Kashyap; Nguvenvu Chu; Aditya Apte; BoPing Wang; Hanli Liu

doi:10.1117/12.700894

13 February 2007 Development of broadband multi-channel NIRS (near-infrared spectroscopy) imaging system for quantification of spatial distribution of hemoglobin derivatives

Dheerendra Kashyap, Nguvenvu Chu, Aditya Apte, BoPing Wang, Hanli Liu

Author Affiliations +

Proceedings Volume 6434, Optical Tomography and Spectroscopy of Tissue VII; 64341X (2007) https://doi.org/10.1117/12.700894
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

In this study, we report the development of a near infrared broadband, steady-state, multi-channel imaging system to quantify hemodynamic parameters, which is to be used for measuring the rat brain tumors in vivo. The imager was calibrated with laboratory phantoms to eliminate spectral effects of the CCD spectrometers, optical fibers, and multiplexer channels. The calibration procedures also help determine the source strength in order to obtain accurate image reconstructions. A multi-channel, multi-wavelength, spectrally constrained reconstruction algorithm is under development to obtain tomographic maps of concentrations of hemoglobin derivatives and reduced scattering coefficients. The developed imaging system and reconstruction algorithm were validated with dynamic multi-tube phantoms.

Citation Download Citation

Dheerendra Kashyap, Nguvenvu Chu, Aditya Apte, BoPing Wang, and Hanli Liu "Development of broadband multi-channel NIRS (near-infrared spectroscopy) imaging system for quantification of spatial distribution of hemoglobin derivatives", Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 64341X (13 February 2007); https://doi.org/10.1117/12.700894

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