You have requested a machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Neither SPIE nor the owners and publishers of the content make, and they explicitly disclaim, any express or implied representations or warranties of any kind, including, without limitation, representations and warranties as to the functionality of the translation feature or the accuracy or completeness of the translations.
Translations are not retained in our system. Your use of this feature and the translations is subject to all use restrictions contained in the Terms and Conditions of Use of the SPIE website.
13 February 2007An inverse Monte-Carlo method for determining tissue optical properties
In this paper, a Monte Carlo based model of diffuse reflectance is introduced to retrieve the light absorption and
scattering coefficients of multi-layered tissue. The model consists of a forward part and an inverse one. The forward
refers to a multi-layered Monte Carlo simulation at a certain source-detector separation, which lead to a time-resolved
profile. The inverse one is a fitting procedure based on Levenberg-Marquardt algorithm using forward model in iteration,
and the intensity in time bins is fitted. The model was tested with independent Monte Carlo simulations and
fiber-optic-based measurement in the deduced absorption and reduced scattering coefficients. Although a high amount of
computation time is needed, this model is developed as a verification standard to these investigation methods using
diffuse approximation to the transport equation. Furthermore, it is adaptable to the complex fiber-optic probe geometries.