Aqueous humor outflow effects of partial thickness channel created by a femtosecond laser in ex-vivo human eyes

Dongyul Chai; Gautam Chaudhary; Ron Kurtz M.D.; Tibor Juhasz

doi:10.1117/12.701416

6 February 2007 Aqueous humor outflow effects of partial thickness channel created by a femtosecond laser in ex-vivo human eyes

Dongyul Chai, Gautam Chaudhary, Ron Kurtz M.D., Tibor Juhasz

Author Affiliations +

Proceedings Volume 6435, Optical Interactions with Tissue and Cells XVIII; 64350O (2007) https://doi.org/10.1117/12.701416
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

The reduced outflow rate caused by the increased resistance through trabecular meshwork (TM) has been thought to be the main reason for elevated intraocular pressure (IOP). It has been demonstrated that femtosecond laser pulses tuned to 1.7 μm wavelength can create the partial thickness channel in the sclera in ex vivo human eyes [1] and aqueous outflow can be increased by these channels in porcine eyes [2]. It was also shown that the outflow rate is reduced over time in ex vivo human eyes [3]. Therefore, the control experiment without laser treatment at the same condition was conducted and showed that outflow was reduced by 1.5 ± 0.8 μl/min at 15mmHg and 1.8 ± 1.0 μl/min at 25mmHg. However, the outflow rate increased by 0.26 μl/min at 15mmHg and 0.15 μl/min at 25mmHg after the partial thickness channel was created, meaning the amount of increased outflow rate might be more than measured considering the outflow reduction in control experiment. We suggest that the femtosecond laser created partial thickness channel can increase the outflow rate and delay the progression of glaucoma.

Citation Download Citation

Dongyul Chai, Gautam Chaudhary, Ron Kurtz M.D., and Tibor Juhasz "Aqueous humor outflow effects of partial thickness channel created by a femtosecond laser in ex-vivo human eyes", Proc. SPIE 6435, Optical Interactions with Tissue and Cells XVIII, 64350O (6 February 2007); https://doi.org/10.1117/12.701416

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available