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13 February 2007 Limitation of photoacoustic burn depth measurement using Monte Carlo analysis
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Early and accurate determination of burn depth is crucial to monitoring the burn wound and aiding in the precise excision of necrotic tissue. A simplified model of a partial-thickness burn wound can be described as a layer of necrotic dermal tissue, containing thermally coagulated blood, atop a layer of inflamed dermal tissue characterized by the presence of viable (non-coagulated) blood. Using photoacoustic methods it is possible to discriminate between coagulated and non-coagulated blood and, therefore, discriminate between the two layer types. However, the effectiveness of such a photoacoustic method is limited by the thickness of the upper coagulated layer. Sufficient laser energy must be deposited into both layers to create detectable and characteristic signals from those layers. To determine the maximum thickness of the coagulated layer, at which the underlying non-coagulated layer was still able to generate detectable acoustic waves, we performed a Monte Carlo simulation on a human burn wound model with varying depths of the coagulated layer. The depths of the coagulated layer ranged from 100 to 1,100 &mgr;m, in 100 &mgr;m increments. Our analysis concluded that burn depth measurements can be achieved up to a burn depth of 900 &mgr;m with an incident radiant exposure of 0.255 J/cm2 at 543nm and 0.1275 J/cm2 at 633 nm.
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Robert J. Talbert and John A. Viator "Limitation of photoacoustic burn depth measurement using Monte Carlo analysis", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 643709 (13 February 2007);

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