Acoustic fingerprints of photoacoustic contrast agents for molecular imaging

Michael A. McDonald; Ladislav Jankovic; Khalid Shahzad; Michael Burcher; King C.P. Li

doi:10.1117/12.702355

13 February 2007 Acoustic fingerprints of photoacoustic contrast agents for molecular imaging

Michael A. McDonald, Ladislav Jankovic, Khalid Shahzad, Michael Burcher, King C.P. Li

Proceedings Volume 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics; 64370L (2007) https://doi.org/10.1117/12.702355
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Protein nanospheres capable of frequency controlled oscillation in response to laser stimulation are presented as contrast agents for photoacoustic imaging. Incident laser energy absorbed by dye-labeled protein nanospheres causes thermoelastically generated sound production. Plotted A-line graphs reveal a distinctive morphology and greater than 2 orders of magnitude increase in signal amplitude subsequent to converting labeled proteins into nanospheres. Evidence of nonlinearity and enhancement of ultrasound backscatter indicate a potential use in contrast-enhanced harmonic imaging. Photoacoustic and ultrasound imaging of protein nanospheres in phantom vessels show enhanced contrast at low concentration and clear delineation of the phantom vessel wall.

Citation Download Citation

Michael A. McDonald, Ladislav Jankovic, Khalid Shahzad, Michael Burcher, and King C.P. Li "Acoustic fingerprints of photoacoustic contrast agents for molecular imaging", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 64370L (13 February 2007); https://doi.org/10.1117/12.702355

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KEYWORDS

Photoacoustic spectroscopy

Ultrasonography

Proteins

Acoustics

Transducers

Tissues

Photoacoustic imaging

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