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13 February 2007 Quantitative in-vivo measurements of blood oxygen saturation using multiwavelength photoacoustic imaging
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Multiwavelength photoacoustic imaging was used to make spatially resolved measurements of blood oxygen saturation (sO2) in vivo. 2D cross-sectional images of the initial absorbed optical energy distribution in the finger were acquired at near-infrared wavelengths using a photoacoustic imaging system. Using the structural information from these images, a 2D finite element forward model of the light transport was formulated to calculate the absorbed energy density in the tissue as a function of the concentrations of the tissue chromophores and scatters. Separate oxy- (HbO2) and deoxyhaemoglobin (HHb) concentrations were assigned to locations within the mesh that corresponded to the locations of blood vessels in the detected photoacoustic image. The surrounding tissue was regarded as a homogeneous medium with optical properties that were determined by the concentrations of water, lipids, optical scatters, and HbO2 and HHb in the capillary bed. The concentrations of the individual chromophores were the variable input parameters of the forward model. By varying their values in a minimisation procedure in order to fit the output of the model to the measured multiwavelength images, the HbO2 and HHb concentrations, and hence blood sO2, within the blood vessels were determined.
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J. Laufer, E. Zhang, and P. Beard "Quantitative in-vivo measurements of blood oxygen saturation using multiwavelength photoacoustic imaging", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 64371Z (13 February 2007);

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