Improved approach to extract absorption coefficient from photoacoustic signal for photoacoustic spectroscopy

Yi Wang; Ruikang Wang

doi:10.1117/12.702245

13 February 2007 Improved approach to extract absorption coefficient from photoacoustic signal for photoacoustic spectroscopy

Yi Wang, Ruikang Wang

Author Affiliations +

Proceedings Volume 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics; 643720 (2007) https://doi.org/10.1117/12.702245
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Previous studies on measurements of hemoglobin concentrations and oxygen saturations of human blood by photoacoustic spectroscopy assume that the exponential attenuation of the optical radiation in blood results in photoacoustic signals with exponential temporal profiles and absorption coefficients could be extracted by fitting exponential functions. In this paper, we demonstrate that the detected photoacoustic signals are the convolutions of the optical absorption distributions in samples, and the first derivative of the temporal profile of the excitation laser, and the impulse response of the ultrasound detector. The detected photoacoustic signals from absorbers with exponential optical absorption distributions do not keep exponential profiles. In addition, we present an improved approach to calculate the absorption coefficient by fitting the detected photoacoustic signal with a function that is the convolution of an exponential function, and the first derivative of the temporal profile of the laser, and the impulse response of the detector. This approach is validated by both numerical simulations and experimental results.

Citation Download Citation

Yi Wang and Ruikang Wang "Improved approach to extract absorption coefficient from photoacoustic signal for photoacoustic spectroscopy", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 643720 (13 February 2007); https://doi.org/10.1117/12.702245

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KEYWORDS

Signal detection

Photoacoustic spectroscopy

Absorption

Blood

Sensors

Signal attenuation

Convolution

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