Oligonucleotide functionalized Fabry-Perot interferometric probe for DNA sequence detection

Xingwei Wang; Juncheng Xu; Zhuang Wang; Kristie L. Cooper; Anbo Wang; Chengdong Cao

doi:10.1117/12.697431

13 February 2007 Oligonucleotide functionalized Fabry-Perot interferometric probe for DNA sequence detection

Xingwei Wang, Juncheng Xu, Zhuang Wang, Kristie L. Cooper, Anbo Wang, Chengdong Cao

Proceedings Volume 6449, Genetically Engineered and Optical Probes for Biomedical Applications IV; 64490G (2007) https://doi.org/10.1117/12.697431
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

This paper presents a novel fiber optic Fabry-Perot (FP) structure for direct detection of deoxyribonucleic acid (DNA) sequences. The capture DNA is immobilized onto the surface of a silica optical fiber tip by means of the layer-by-layer electrostatic self-assembly (L-b-L ESA) technique. With the FP cavity inside the fiber, the change in optical path length difference (OPD) caused by the immobilization and hybridization can be demodulated. Experimental results demonstrate short (~5 min) response time. In addition, the sensor fabrication is simple and low cost. The signal is stable with high visibility.

Citation Download Citation

Xingwei Wang, Juncheng Xu, Zhuang Wang, Kristie L. Cooper, Anbo Wang, and Chengdong Cao "Oligonucleotide functionalized Fabry-Perot interferometric probe for DNA sequence detection", Proc. SPIE 6449, Genetically Engineered and Optical Probes for Biomedical Applications IV, 64490G (13 February 2007); https://doi.org/10.1117/12.697431

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