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14 February 2007 Biochemical detection with optical whispering-gallery resonaters
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Abstract
We demonstrate biochemical detection based upon specific binding of untagged analytes to modified surfaces of high-Q optical microresonators with whispering-gallery (WG) modes. Extremely small absolute amounts of bound analyte, down to 0.25 fmol of streptavidin, are detected via displacement of the resonance frequencies of the WG modes. The sensitized microresonators are dry and storable, and the flow cell sensor design lends itself to cheap, expendable fabrication.
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Ying Lin, Vladimir Ilchenko, Jay Nadeau, and Lute Maleki "Biochemical detection with optical whispering-gallery resonaters", Proc. SPIE 6452, Laser Resonators and Beam Control IX, 64520U (14 February 2007); https://doi.org/10.1117/12.716591
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