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9 February 2007 Optical DNA sensing based on resonant porous silicon structures
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Porous silicon is a suitable host material for biosensing applications due to its high surface area to volume ratio, which enables substantial infiltration of biomolecules. Resonant waveguides can be fabricated from porous silicon based on a two layer porous silicon structure. Light is coupled into the waveguide only at a particular angle of incidence. Biomolecular binding inside the pores induces an increase in the effective porous silicon refractive index and causes a change in the angle at which light is coupled into the waveguide. A biosensor for DNA detection based on a porous silicon waveguide has been fabricated. Detection of DNA at concentrations on the level of ~μM is reported. Simulations suggest significantly lower detection levels are possible.
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Guoguang Rong and Sharon M. Weiss "Optical DNA sensing based on resonant porous silicon structures", Proc. SPIE 6477, Silicon Photonics II, 647717 (9 February 2007);

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