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13 March 2007Intensity-modulated fluence patterns for task-specific imaging in cone-beam CT
Cone-beam CT images of a patient with a pre-defined distribution of noise in the image and dose to the patient can be
accomplished through the development of advanced compensation schemes. Such compensation schemes involve
delivery of x-ray fluence patterns that vary in intensity both across a single projection image (u,v) and for different
projection view angles (θ) and provide the ability to perform intensity-modulated cone-beam CT. Implementation of an
intensity-modulated cone-beam CT system for task-specific imaging has potential for tremendous reductions in patient
dose and x-ray scatter reaching the detector. Pursuing this advanced imaging technique requires detailed characterization
of the cone-beam CT platform. Determination of appropriately modulated fluence patterns relies on knowledge of
numerous properties of the imaging system, including the constraints imposed by the modulator, the magnitude of x-ray
scatter under different patient sizes and modulator positions, and properties of the detector. With an estimate of the
patient anatomy and knowledge of the imaging system, an iterative process can be used to determine modulated fluence
patterns corresponding to an image prescribed for the specific task and patient. Delivery of such modulated fluence
patterns provide a CBCT image tailored to a specific patient and imaging task offering the optimum balance between
image quality and patient dose. Specifically, arbitrary regions of interest requiring high image signal-to-noise ratio can
be generated through knowledgeable spatio-angular intensity modulation, allowing image quality to degrade in other
regions in order to minimize x-ray scatter and imaging dose.
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S. A. Graham, J. H. Siewerdsen, D. A. Jaffray, "Intensity-modulated fluence patterns for task-specific imaging in cone-beam CT," Proc. SPIE 6510, Medical Imaging 2007: Physics of Medical Imaging, 651003 (13 March 2007); https://doi.org/10.1117/12.713724