Development and implementation of a high-performance cardiac-gated dual-energy imaging system

N. A. Shkumat; J. H. Siewerdsen; A. C. Dhanantwari; D. B. Williams; S. Richard; D. J Tward; N. S. Paul; J. Yorkston; R. Van Metter

doi:10.1117/12.713680

20 March 2007 Development and implementation of a high-performance, cardiac-gated dual-energy imaging system

N. A. Shkumat, J. H. Siewerdsen, A. C. Dhanantwari, D. B. Williams, S. Richard, D. J Tward, N. S. Paul, J. Yorkston, R. Van Metter

Author Affiliations +

Proceedings Volume 6510, Medical Imaging 2007: Physics of Medical Imaging; 651006 (2007) https://doi.org/10.1117/12.713680
Event: Medical Imaging, 2007, San Diego, CA, United States

Abstract

Mounting evidence suggests that the superposition of anatomical clutter in a projection radiograph poses a major impediment to the detectability of subtle lung nodules. Through decomposition of projections acquired at multiple kVp, dual-energy (DE) imaging offers to dramatically improve lung nodule detectability and, in part through quantitation of nodule calcification, increase specificity in nodule characterization. The development of a high-performance DE chest imaging system is reported, with design and implementation guided by fundamental imaging performance metrics. A diagnostic chest stand (Kodak RVG 5100 digital radiography system) provided the basic platform, modified to include: (i) a filter wheel, (ii) a flat-panel detector (Trixell Pixium 4600), (iii) a computer control and monitoring system for cardiac-gated acquisition, and (iv) DE image decomposition and display. Computational and experimental studies of imaging performance guided optimization of key acquisition technique parameters, including: x-ray filtration, allocation of dose between low- and high-energy projections, and kVp selection. A system for cardiac-gated acquisition was developed, directing x-ray exposures to within the quiescent period of the heart cycle, thereby minimizing anatomical misregistration. A research protocol including 200 patients imaged following lung nodule biopsy is underway, allowing preclinical evaluation of DE imaging performance relative to conventional radiography and low-dose CT.

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N. A. Shkumat, J. H. Siewerdsen, A. C. Dhanantwari, D. B. Williams, S. Richard, D. J Tward, N. S. Paul, J. Yorkston, and R. Van Metter "Development and implementation of a high-performance, cardiac-gated dual-energy imaging system", Proc. SPIE 6510, Medical Imaging 2007: Physics of Medical Imaging, 651006 (20 March 2007); https://doi.org/10.1117/12.713680

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