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29 March 2007 Pseudo-enhancement correction for computer-aided detection in fecal-tagging CT colonography
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Fecal-tagging CT colonography (CTC) presents an opportunity to minimize colon cleansing while maintaining high diagnostic accuracy for the detection of colorectal lesions. However, the pseudo-enhancement introduced by tagging agents presents several problems for the application of computer-aided detection (CAD). We developed a correction method that minimizes pseudo-enhancement in CTC data by modeling of the pseudo-enhancement as a cumulative Gaussian energy distribution. The method was optimized by use of an anthropomorphic colon phantom, and its effect on our fully automated CAD scheme was tested by use of leave-one-patient-out evaluation on 23 clinical CTC cases with reduced colon cleansing based upon dietary fecal tagging. There were 28 colonoscopy-confirmed polyps ≥6 mm. Visual evaluation indicated that the method reduced CT attenuation of pseudo-enhanced polyps to standard soft-tissue Hounsfield unit (HU) range without affecting untagged regions. At a 90% detection sensitivity for polyps ≥6 mm, CAD yielded 8.5 false-positive (FP) detections and 3.9 FP detections per volumetric scan without and with the application of the pseudo-enhancement correction method. These results indicate that the pseudo-enhancement correction method is a potentially useful pre-processing step for automated detection of polyps in fecal-tagging CTC, and that CAD can yield a high detection sensitivity with a relatively low FP rate in CTC with patient-friendly reduced colon preparation.
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Janne Näppi, Hiroyuki Yoshida, Michael Zalis, Wenli Cai, and Philippe Lefere "Pseudo-enhancement correction for computer-aided detection in fecal-tagging CT colonography", Proc. SPIE 6514, Medical Imaging 2007: Computer-Aided Diagnosis, 65140A (29 March 2007);

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