Experimental investigation of magnetic nanotubes in PC-12 neuron cells culturing

Linfeng Chen; Jining Xie; J. Yancey; Malathi Srivatsan; Vijay K. Varadan

doi:10.1117/12.717970

11 April 2007 Experimental investigation of magnetic nanotubes in PC-12 neuron cells culturing

Linfeng Chen, Jining Xie, J. Yancey, Malathi Srivatsan, Vijay K. Varadan

Proceedings Volume 6528, Nanosensors, Microsensors, and Biosensors and Systems 2007; 65280L (2007) https://doi.org/10.1117/12.717970
Event: SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, 2007, San Diego, California, United States

Abstract

This report discusses the effects of magnetic nanotubes on the differentiation and growth of neurons. The magnetic nanotubes used in this study are hematite nanotubes synthesized using template method, and their structural and magnetic properties have been characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM). PC-12 cells are differentiated into neurons in the presence of magnetic nanotubes to confirm the biocompatibility and cytotoxic effects of magnetic nanotubes during the processes of neuron differentiation and neuronal growth. The morphological changes and synapse formation of neurons are investigated, and the contact effects of magnetic nanotubes on neurite (axon and dendrites) outgrowth are explored. This research allows us to understand the interaction between magnetic nanomaterials and neurons, and pave the way towards developing potential treatments using the magnetic nano tubes for neurodegenerative disorders and injuries to the nervous system in the future.

Citation Download Citation

Linfeng Chen, Jining Xie, J. Yancey, Malathi Srivatsan, and Vijay K. Varadan "Experimental investigation of magnetic nanotubes in PC-12 neuron cells culturing", Proc. SPIE 6528, Nanosensors, Microsensors, and Biosensors and Systems 2007, 65280L (11 April 2007); https://doi.org/10.1117/12.717970

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available