Absorption spectrum characteristic of chorophyll derivatives photosensitizer CPD3

Fenghua Xiang; Hui Liu; Youshan Lu; Ping Chen D.D.S.; Guoqing Tang

doi:10.1117/12.741634

1 May 2007 Absorption spectrum characteristic of chorophyll derivatives photosensitizer CPD₃

Fenghua Xiang, Hui Liu, Youshan Lu, Ping Chen D.D.S., Guoqing Tang

Proceedings Volume 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine; 653425 (2007) https://doi.org/10.1117/12.741634
Event: Fifth International Conference on Photonics and Imaging in Biology and Medicine, 2006, Wuhan, China

Abstract

Absorption spectrum of CPD₃ is determined. There are two absorption bands all in absorption spectrum, the maximal absorption of band B is at 395nm in 0.9% NaCl solution and TE buffer solution, the band Q is locating at 677nm and 651nm respectively in solvents above. The order of magnitude of extinction coefficient is 10⁴ in both solvents. the absorption peak of CPD₃-DNA mix solution have 6nm and 23nm red shift for band B and band Q respectively compared with pure CPD₃ in 0.9% NaCl solution, this indicates that interaction between photosensitizer and DNA occurring. Time series data of absorption for CPD₃-DNA mix solution supports the interaction viewpoint further, and the full action time is about 90mins. The type of interaction needs a further investigating. Stronger absorption in red region and the interaction with DNA suggests that CPD₃ will have a bright future in photodynamic therapy.

Citation Download Citation

Fenghua Xiang, Hui Liu, Youshan Lu, Ping Chen D.D.S., and Guoqing Tang "Absorption spectrum characteristic of chorophyll derivatives photosensitizer CPD₃", Proc. SPIE 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine, 653425 (1 May 2007); https://doi.org/10.1117/12.741634

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KEYWORDS

Absorption

Photodynamic therapy

Mass attenuation coefficient

Cancer

Chlorine

Luminescence

Molecules

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