Spontaneous generation and disappearance of burst firing in cultured neuronal network

Man Liu; Wei Zhou; Xiangning Li; Qingming Luo

doi:10.1117/12.741468

1 May 2007 Spontaneous generation and disappearance of burst firing in cultured neuronal network

Man Liu, Wei Zhou, Xiangning Li, Qingming Luo

Proceedings Volume 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine; 65343F (2007) https://doi.org/10.1117/12.741468
Event: Fifth International Conference on Photonics and Imaging in Biology and Medicine, 2006, Wuhan, China

Abstract

Burst as a unit of information coding is widely investigated in the developing central nervous system. However the mechanism underling the bursts generate and disappear is unclear at present. Neurons cultured on the multi-electrode arrays, are spontaneously active, and show complex pattern with random spikes and bursts firing. With long-term recording, the course of bursts generation and disappearance was detected. The results showed that the firing pattern could transform from random spikes to bursts firing. In the beginning, the random spikes rate decreased, accompanied with bursts occurred once in a while. It appeared both single spikes and bursts at the same time. After that, the random spikes disappeared. Spontaneous activity displayed a regular occurrence of bursts with shorter interspike interval. During such bursts the firing rate at the active sites was increased dramatically. After several seconds, firing rate decreased, interburst interval extended, accompanied with the occurrence of random spikes, opposite to the beginning. At last, bursts disappeared and the networks just fired in random spikes. The observation showed that the complex electrophysiological activities of the cultured neuronal networks could implicate the spontaneous generation of burst firing. Understanding how bursts generate and disappear might be significant for deeply investigating the function and mechanism of bursts information coding.

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Man Liu, Wei Zhou, Xiangning Li, and Qingming Luo "Spontaneous generation and disappearance of burst firing in cultured neuronal network", Proc. SPIE 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine, 65343F (1 May 2007); https://doi.org/10.1117/12.741468

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KEYWORDS

Neurons

Nervous system

In vitro testing

Signal detection

Computer programming

Electrodes

Photonics

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