Investigation of glucose-hemoglobin interaction by optical coherence tomography

Olga S. Zhernovaya; Alexey N. Bashkatov; Elina A. Genina; Valery V. Tuchin; Igor V. Meglinski; Dmitry Yu. Churmakov; Laurie J. Ritchie

doi:10.1117/12.740985

26 April 2007 Investigation of glucose-hemoglobin interaction by optical coherence tomography

Olga S. Zhernovaya, Alexey N. Bashkatov, Elina A. Genina, Valery V. Tuchin, Igor V. Meglinski, Dmitry Yu. Churmakov, Laurie J. Ritchie

Author Affiliations +

Proceedings Volume 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII; 65351C (2007) https://doi.org/10.1117/12.740985
Event: Saratov Fall Meeting 2006, 2006, Saratov, Russian Federation

Abstract

In this study, the refractive index of glucose-hemoglobin solutions at different glucose concentrations was measured. Measurements were performed using Abbe refractometer at 589 nm and OCT system at 1300 nm. The different amount of glucose was added to hemoglobin solution. Theoretical values of refractive index of the glucose-hemoglobin solutions were calculated in assumption that hemoglobin and glucose molecules do not interact. The difference between the measured and calculated values of refractive index can be connected with glucose binding to hemoglobin. It is shown that the refractive index measurements can be applied to the evaluation of glycated hemoglobin amount.

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Olga S. Zhernovaya, Alexey N. Bashkatov, Elina A. Genina, Valery V. Tuchin, Igor V. Meglinski, Dmitry Yu. Churmakov, and Laurie J. Ritchie "Investigation of glucose-hemoglobin interaction by optical coherence tomography", Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 65351C (26 April 2007); https://doi.org/10.1117/12.740985

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