Measuring changes in the scattering properties of Intralipid at different depths with optical coherence tomography

Matti Kinnunen; Risto Myllylä

doi:10.1117/12.753458

20 June 2007 Measuring changes in the scattering properties of Intralipid at different depths with optical coherence tomography

Matti Kinnunen, Risto Myllylä

Author Affiliations +

Proceedings Volume 6536, Saratov Fall Meeting 2006: Coherent Optics of Ordered and Random Media VII; 65360N (2007) https://doi.org/10.1117/12.753458
Event: Saratov Fall Meeting 2006, 2006, Saratov, Russian Federation

Abstract

Optical coherence tomography (OCT) is a powerful tool for imaging tissue structure. The images provide information on a micrometer scale. By averaging depth scans, an intensity profile can be formed as a function of depth. The slope of a straight line fitted to the OCT signal depth profile contains information on light attenuation in the sample at different depths. This slope can be used to detect changes in the scattering properties of the sample, especially in a single scattering region. In this article, the effect of fitting the line at different depths on detection sensitivity was studied in Intralipid phantoms with different concentrations. Different glucose concentrations were also used with 5 % Intralipid samples. Different depths were studied because the depth of the dermis and the thicknesses of skin layers in human skin vary in different body locations. The results show that the sensitivity of detecting changes in the scattering properties of Intralipid is better at a depth corresponding to that of the dermis in the human arm (0.166 - 0.276 mm) than at a depth equaling the dermis in the forefinger (0.441 - 0.579 mm). For this reason, the applicability of the single scattering model for fitting the straight line to different depths of the OCT signal is limited, and a more comprehensive model for extracting changes in scattering is recommended at greater depths. This has to be kept in mind when determining the depth position for registering glucose-induced changes in vivo with an OCT-based glucose sensor.

Citation Download Citation

Matti Kinnunen and Risto Myllylä "Measuring changes in the scattering properties of Intralipid at different depths with optical coherence tomography", Proc. SPIE 6536, Saratov Fall Meeting 2006: Coherent Optics of Ordered and Random Media VII, 65360N (20 June 2007); https://doi.org/10.1117/12.753458

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