Selective functionalization of II-VI semiconductor quantum dots with peptides and integrins of cancer cells for biophotonic applications

Bakhysh Bairamov; Vladimir Toporov; Farid Bayramov; Vladislav Lanzov; Mitra Dutta; Michael A. Stroscio; G. Irmer

doi:10.1117/12.723031

22 May 2007 Selective functionalization of II-VI semiconductor quantum dots with peptides and integrins of cancer cells for biophotonic applications

Bakhysh Bairamov, Vladimir Toporov, Farid Bayramov, Vladislav Lanzov, Mitra Dutta, Michael A. Stroscio, G. Irmer

Author Affiliations +

Proceedings Volume 6592, Bioengineered and Bioinspired Systems III; 65920W (2007) https://doi.org/10.1117/12.723031
Event: Microtechnologies for the New Millennium, 2007, Maspalomas, Gran Canaria, Spain

Abstract

Nanoscale functionalization of semiconductor quantum dots (SQDs) with biomedical structures is promising for many applications and novel studies of intrinsic properties of both constituent systems. Results of our study of structural properties of the nanoscale functionalized SQDs such as CdS, and ZnS-capped CdSe SQDs, conjugated with biomolecules such as short peptides and cells are presented. We study CdS SQDs functionalized with peptides specially composed of the following amino acid chains: CGGGRGDS, CGGGRVDS, CGGIKVAV, and CGGGLDV, where R is arginine, D - aspartic acid, S - serine, V - valine, K - lysine and L is Levine. As will be seen the cysteine (C) amino acid links to CdS SQDs via the thiol link, the GGG sequences of glycine (G) amino acid, provide a spacer in the amino acid chain. At the same time the RGDS, RVDS, IKAV, and LDV sequences have selective bonding affinities to specialized transmembrane cellular structures known as integrins of neurons and MDA-MB-435 cancer cells, respectively. We found that the quantum confinement and functionalizing in biomedical environments plays in altering and determining the electronic, optical, and vibrational properties of these nanostructures as well as demonstrated the effectiveness to use semiconductor quantum dots as integrin sensitive biotags.

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Bakhysh Bairamov, Vladimir Toporov, Farid Bayramov, Vladislav Lanzov, Mitra Dutta, Michael A. Stroscio, and G. Irmer "Selective functionalization of II-VI semiconductor quantum dots with peptides and integrins of cancer cells for biophotonic applications", Proc. SPIE 6592, Bioengineered and Bioinspired Systems III, 65920W (22 May 2007); https://doi.org/10.1117/12.723031

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KEYWORDS

Cadmium sulfide

Quantum dots

Luminescence

Biomedical optics

Cancer

Semiconductors

Proteins

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