Quantification of the outer retinal layers: correlation to visual acuity in healthy subjects and patients with central serous chorioretinopathy

Birgit Sander; Ulrik Christensen; Michael Larsen; Thomas M. Jørgensen

doi:10.1117/12.729548

11 July 2007 Quantification of the outer retinal layers: correlation to visual acuity in healthy subjects and patients with central serous chorioretinopathy

Birgit Sander, Ulrik Christensen, Michael Larsen, Thomas M. Jørgensen

Author Affiliations +

Proceedings Volume 6627, Optical Coherence Tomography and Coherence Techniques III; 66271M (2007) https://doi.org/10.1117/12.729548
Event: European Conferences on Biomedical Optics, 2007, Munich, Germany

Abstract

Purpose: Quantification of outer retinal layers in humans. Method: 11 eyes in healthy subjects and 3 eyes in patients after resolution of central serous chorioretinopathy (CSCR). Multiple line scans were obtained using OCT Stratus and scans were registered and averaged to enhance contrast. The distance from the inner-outer segment junction to the posterior part of the retinal pigment epithelium (RPE-OS_complex) was calculated. In addition, the reflectance of the outer photoreceptor layer in the foveal center was compared to that peripheral to the fovea. Results: Mean thickness of the RPE-OS_complex in healthy subjects was 77.3 μm, in CSCR 52.9 μm. The thickness of the RPE-OS_complex was significantly correlated to visual acuity (r=0.95, p<0.01). The ratio of reflectance (fovea/parafovea) was 1.06 in healthy subjects, 1.18 in CSCR eyes. Conclusion: The RPE-OS_complex thickness was markedly reduced in eyes after resolution of CSCR and highly correlated to the visual acuity, the correlation to total foveal thickness was less. An increased backscatter was seen in CSCR, probably due to photoreceptor disorganization and atrophy.

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Birgit Sander, Ulrik Christensen, Michael Larsen, and Thomas M. Jørgensen "Quantification of the outer retinal layers: correlation to visual acuity in healthy subjects and patients with central serous chorioretinopathy", Proc. SPIE 6627, Optical Coherence Tomography and Coherence Techniques III, 66271M (11 July 2007); https://doi.org/10.1117/12.729548

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KEYWORDS

Visualization

Optical coherence tomography

Image segmentation

Reflectivity

Retina

Tissues

Backscatter

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