Imaging of hemodynamic effects in arthritic joints with dynamic optical tomography

Andreas H. Hielscher; Joseph M. Lasker; Christopher J. Fong; Edward Dwyer

doi:10.1117/12.728576

12 July 2007 Imaging of hemodynamic effects in arthritic joints with dynamic optical tomography

Andreas H. Hielscher, Joseph M. Lasker, Christopher J. Fong, Edward Dwyer

Proceedings Volume 6629, Diffuse Optical Imaging of Tissue; 66290N (2007) https://doi.org/10.1117/12.728576
Event: European Conferences on Biomedical Optics, 2007, Munich, Germany

Abstract

Optical probing of hemodynamics is often employed in areas such as brain, muscular, and breast-cancer imaging. In these studies an external stimulus is applied and changes in relevant physiological parameters, e.g. oxy or deoxyhemoglobin concentrations, are determined. In this work we present the first application of this method for characterizing joint diseases, especially effects of rheumatoid arthritis (RA) in the proximal-interphalangeal (PIP) finger joints. Using a dual-wavelength tomographic imaging system together with previously implemented model-based iterative image reconstruction schemes, we have performed dynamic imaging case studies on a limited number of healthy volunteers and patients diagnosed with RA. Inflating a sphygmomanometer cuff placed around the forearm we elicited a controlled vascular response. We observed pronounced differences between the hemodynamic effect occurring in healthy volunteers and patients affected by RA.

Citation Download Citation

Andreas H. Hielscher, Joseph M. Lasker, Christopher J. Fong, and Edward Dwyer "Imaging of hemodynamic effects in arthritic joints with dynamic optical tomography", Proc. SPIE 6629, Diffuse Optical Imaging of Tissue, 66290N (12 July 2007); https://doi.org/10.1117/12.728576

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available