Time-resolved diffuse reflectance at small source-detector separation using a time-gated single-photon avalanche diode

Antonio Pifferi; Alessandro Torricelli; Lorenzo Spinelli; Davide Contini; Rinaldo Cubeddu; Fabrizio Martelli; Giovanni Zaccanti; Alberto Tosi; Alberto Dalla Mora; Franco Zappa; Sergio Cova

doi:10.1117/12.727947

17 July 2007 Time-resolved diffuse reflectance at small source-detector separation using a time-gated single-photon avalanche diode

Antonio Pifferi, Alessandro Torricelli, Lorenzo Spinelli, Davide Contini, Rinaldo Cubeddu, Fabrizio Martelli, Giovanni Zaccanti, Alberto Tosi, Alberto Dalla Mora, Franco Zappa, Sergio Cova

Author Affiliations +

Proceedings Volume 6631, Novel Optical Instrumentation for Biomedical Applications III; 66310B (2007) https://doi.org/10.1117/12.727947
Event: European Conferences on Biomedical Optics, 2007, Munich, Germany

Abstract

We demonstrate the feasibility of time-resolved diffuse reflectance at small source-detector separations using a single-photon avalanche diode (SPAD) operated in time-gated mode. Photon time distributions at an interfiber distance of 0.2 cm were obtained on tissue phantoms with a reduced scattering coefficient of 10 cm^-1, and an absorption coefficient of 0.1 cm^-1, with a dynamic range of 10⁶ and collecting photons at arrival times up to 4 ns. By time-gating the initial photons, carrying information mainly from superficial layers, it is possible to detect longer lived photons that have explored deeper depths even at almost null interfiber distances. The proposed approach should provide higher number of photons at any arrival time, higher contrast, and better spatial resolution as compared to longer interfiber distances.

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Antonio Pifferi, Alessandro Torricelli, Lorenzo Spinelli, Davide Contini, Rinaldo Cubeddu, Fabrizio Martelli, Giovanni Zaccanti, Alberto Tosi, Alberto Dalla Mora, Franco Zappa, and Sergio Cova "Time-resolved diffuse reflectance at small source-detector separation using a time-gated single-photon avalanche diode", Proc. SPIE 6631, Novel Optical Instrumentation for Biomedical Applications III, 66310B (17 July 2007); https://doi.org/10.1117/12.727947

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