Fluorescence imaging of experimental rheumatoid arthritis in vivo using a fast flying-spot scanner

J. Berger; J. Voigt; F. Seifert; B. Ebert; R. Macdonald; I. Gemeinhardt; O. Gemeinhardt; J. Schnorr; M. Taupitz; A. Vater; S. Vollmer; K. Licha; M. Schirner

doi:10.1117/12.728307

18 July 2007 Fluorescence imaging of experimental rheumatoid arthritis in vivo using a fast flying-spot scanner

J. Berger, J. Voigt, F. Seifert, B. Ebert, R. Macdonald, I. Gemeinhardt, O. Gemeinhardt, J. Schnorr, M. Taupitz, A. Vater, S. Vollmer, K. Licha, M. Schirner

Author Affiliations +

Proceedings Volume 6631, Novel Optical Instrumentation for Biomedical Applications III; 66310U (2007) https://doi.org/10.1117/12.728307
Event: European Conferences on Biomedical Optics, 2007, Munich, Germany

Abstract

We have developed a flying-spot scanner for fluorescence imaging of rheumatoid arthritis in the near infrared (NIR) spectral range following intravenous administration of contrast agents. The new imaging system has been characterized with respect to linearity, dynamic range and spatial resolution with the help of fluorescent phantoms. In vivo experiments were performed on an animal model of rheumatoid arthritis. Finally, NIR-fluorescence images of early stages of joint inflammation have been compared with findings from contrast enhanced MR imaging and histology.

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J. Berger, J. Voigt, F. Seifert, B. Ebert, R. Macdonald, I. Gemeinhardt, O. Gemeinhardt, J. Schnorr, M. Taupitz, A. Vater, S. Vollmer, K. Licha, and M. Schirner "Fluorescence imaging of experimental rheumatoid arthritis in vivo using a fast flying-spot scanner", Proc. SPIE 6631, Novel Optical Instrumentation for Biomedical Applications III, 66310U (18 July 2007); https://doi.org/10.1117/12.728307

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