Optimization of an advanced non-invasive light activated disinfection strategy

S. George; A. Kishen

doi:10.1117/12.729439

13 July 2007 Optimization of an advanced non-invasive light activated disinfection strategy

S. George, A. Kishen

Proceedings Volume 6633, Biophotonics 2007: Optics in Life Science; 663318 (2007) https://doi.org/10.1117/12.729439
Event: European Conferences on Biomedical Optics, 2007, Munich, Germany

Abstract

A photosensitizer formulation and strategy was developed based on the photophysical, photochemical and photobiological characteristics of methylene blue (MB) for the disinfection of root canal using light activated therapy. Disinfection of matured E. faecalis biofilms on root canal dentine was tried with the newly developed 'Advanced Non- Invasive Light Activated Disinfection' (ANILAD), conventional photodynamic therapy, and conventional root canal therapy alone or in combination with ANILAD. The results showed that, although complete disinfection of nonmatured biofilm is possible by ANILAD alone, a combination of conventional root canal treatment (RCT) with ANILAD could achieve significantly higher bacterial killing (6log₁₀-7log₁₀ bacterial reduction) compared to any other tested treatment in matured biofilm (p<0.001).

Citation Download Citation

S. George and A. Kishen "Optimization of an advanced non-invasive light activated disinfection strategy", Proc. SPIE 6633, Biophotonics 2007: Optics in Life Science, 663318 (13 July 2007); https://doi.org/10.1117/12.729439

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