Evaluation of drug release from PLGA nanospheres containing bethametasone

Mohammad E. Khosroshahi; Marjan Enayati; Sara Shafiei; Javad Tavakoli

doi:10.1117/12.724480

13 July 2007 Evaluation of drug release from PLGA nanospheres containing bethametasone

Mohammad E. Khosroshahi, Marjan Enayati, Sara Shafiei, Javad Tavakoli

Proceedings Volume 6633, Biophotonics 2007: Optics in Life Science; 66331E (2007) https://doi.org/10.1117/12.724480
Event: European Conferences on Biomedical Optics, 2007, Munich, Germany

Abstract

In this research poly (d,l-lactide-coglycolide acid) (PLGA) as polymeric nanospheres, poly(vinyl alcohol) (PVA) with 87-89% hydrolysis degree as surfactant and distilled water as suspending medium were used. The encapsulated drug was Bethametasone. The nanospheres were prepared by an emulsion-solvent evaporation method. The nanospheres characterized by photon correlation spectroscopy (PCS) and scanning electron microscopy (SEM). The amount of drug release was determined by HPLC. In emulsion-solvent evaporation technique, time of ultrasound exposure, surfactant content in the formulation and evaporation rate of organic solvents were considered as formulation variables.

Citation Download Citation

Mohammad E. Khosroshahi, Marjan Enayati, Sara Shafiei, and Javad Tavakoli "Evaluation of drug release from PLGA nanospheres containing bethametasone", Proc. SPIE 6633, Biophotonics 2007: Optics in Life Science, 66331E (13 July 2007); https://doi.org/10.1117/12.724480

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