Photophysical properties of photosensitizer chlorin e6 incorporated into polyvinylpyrrolidone

M. V. Parkhats; V. N. Knyukshto; H. A. Isakau; P. T. Petrov; B. M. Dzhagarov

doi:10.1117/12.752494

9 July 2007 Photophysical properties of photosensitizer chlorin e₆ incorporated into polyvinylpyrrolidone

M. V. Parkhats, V. N. Knyukshto, H. A. Isakau, P. T. Petrov, B. M. Dzhagarov

Proceedings Volume 6727, ICONO 2007: Nonlinear Laser Spectroscopy and High-Precision Measurements; and Fundamentals of Laser Chemistry and Biophotonics; 67272L (2007) https://doi.org/10.1117/12.752494
Event: The International Conference on Coherent and Nonlinear Optics, 2007, Minsk, Belarus

Abstract

It has been demonstrated that chlorin e₆ form molecular complex with polyvinylpyrrolidone. The binding constant and the number of binding sites have been determined as Κ= (2.5 ± 0.5)•10⁴ M^-1 and N = 2.1 ± 0.5, respectively. Complex in comparison with free chlorin e₆ possesses increased fluorescence quantum yield, triplet and singlet state lifetimes, slightly modified intersystem crossing quantum yield, and also more intensive and red shifted absorption band locating in the "phototherapeutic window" of biological tissues. The photophysical properties of chlorin e₆ incorporated into the polymer are insensitive to pH. The formation of the complex leads to the disruption of chlorin e₆ aggregates at acidic pH. Binding to polymer only slightly improves photophysical properties of photosensitizer and should not provoke fundamental changes in PDT efficiency.

Citation Download Citation

M. V. Parkhats, V. N. Knyukshto, H. A. Isakau, P. T. Petrov, and B. M. Dzhagarov "Photophysical properties of photosensitizer chlorin e₆ incorporated into polyvinylpyrrolidone", Proc. SPIE 6727, ICONO 2007: Nonlinear Laser Spectroscopy and High-Precision Measurements; and Fundamentals of Laser Chemistry and Biophotonics, 67272L (9 July 2007); https://doi.org/10.1117/12.752494

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