Skin optical clearing enhancement with penetration enhancer azone using spectroscopy and optical coherence tomography

Xiangqun Xu; Qiuhong Zhu

doi:10.1117/12.803974

9 June 2008 Skin optical clearing enhancement with penetration enhancer azone using spectroscopy and optical coherence tomography

Xiangqun Xu, Qiuhong Zhu

Author Affiliations +

Proceedings Volume 6791, Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX; 67910F (2008) https://doi.org/10.1117/12.803974
Event: Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX, 2006, Saratov, Russian Federation

Abstract

In order to find a non-invasive way to improve the efficacy of skin optical clearing with topically applied optical clearing agents (OCA), we evaluated the effect of azone ® (epsilon-Laurocapram) as a chemical penetration enhancer on optical clearing of intact skin in vitro. Fresh porcine skin with topical application of glycerol (G) mixed with water-soluble azone (A) was investigated using near-infrared spectroscopy and optical coherence tomography (OCT). Light transmittance at 1276 nm increased by 41% and diffuse reflectance at 1066 nm decreased by 29% at 60 min after treatment with 40%G5%A on a spectrophotometer with an internal integrating sphere. 40% glycerol with addition of azone was a more effective optical clearing agent than 40% and 80% glycerol. 60%G/5%A led to a 2-fold increase in achievable OCT imaging depth and a 2.2-fold increase in light intensity reflected off the underneath needle surface after 60 minutes in the OCT in-depth reflectance profiles. In conclusion, skin optical clearing with the topical application of glycerol was markedly enhanced by water-soluble azone. Skin permeation enhancing effect of azone accounts probably for the skin clearing enhancement.

Citation Download Citation

Xiangqun Xu and Qiuhong Zhu "Skin optical clearing enhancement with penetration enhancer azone using spectroscopy and optical coherence tomography", Proc. SPIE 6791, Saratov Fall Meeting 2007: Optical Technologies in Biophysics and Medicine IX, 67910F (9 June 2008); https://doi.org/10.1117/12.803974

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