Synthesis and dual fluorescence property of novel dihydroxy phosphorus tetrabenzotriazacorrole derivates

Lei Huang; Peng Zhao; Fushi Zhang; Zhongyu Li; Chenho Tung

doi:10.1117/12.757360

8 January 2008 Synthesis and dual fluorescence property of novel dihydroxy phosphorus tetrabenzotriazacorrole derivates

Lei Huang, Peng Zhao, Fushi Zhang, Zhongyu Li, Chenho Tung

Proceedings Volume 6826, Optics in Health Care and Biomedical Optics III; 68261K (2008) https://doi.org/10.1117/12.757360
Event: Photonics Asia 2007, 2007, Beijing, China

Abstract

Photodynamic diagnosis (PDD) is of increasing interest for diagnosis in oncology. It is based on the selective accumulation of photosensitizers in tumours, such as porphyrin and phthalocyanine. In the present study, novel dihydroxy phosphorus tetrabenzotriazacorrole derivates have been synthesized. And photophysical properties of these derivates have been studied. Dihydroxy phosphorus tetrabenzotriazacorrole derivates display a fluorescence which is from the higher S₂ electronic state. With excitation at 614 nm, the fluorescence maximum is at 668 nm for dihydroxy phosphorus(V)-2,9,16,23-tetranitrotetrabenzotriazacorrole {P(OH)₂TBC(NO₂)₄} in N,N-dimethylformamide (DMF). But with excitation at 310 nm for P(OH)₂TBC(NO₂)₄ in DMF, in addition to S₁ fluorescence a new fluorescence peak appears at 490 nm, which is attributed to S₂-state fluorescence. It indicates that the dihydroxy phosphorus tetrabenzotriazacorrole derivates might have a potential application as a dual fluorescent marker for photodynamic diagnosis.

Citation Download Citation

Lei Huang, Peng Zhao, Fushi Zhang, Zhongyu Li, and Chenho Tung "Synthesis and dual fluorescence property of novel dihydroxy phosphorus tetrabenzotriazacorrole derivates", Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 68261K (8 January 2008); https://doi.org/10.1117/12.757360

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