Laser induced fluorescence imaging system for localization of nasopharyngeal carcinoma

Lina Liu; Shusen Xie

doi:10.1117/12.755102

8 January 2008 Laser induced fluorescence imaging system for localization of nasopharyngeal carcinoma

Lina Liu, Shusen Xie

Proceedings Volume 6826, Optics in Health Care and Biomedical Optics III; 68262M (2008) https://doi.org/10.1117/12.755102
Event: Photonics Asia 2007, 2007, Beijing, China

Abstract

A laser induced fluorescence imaging system for localization of Nasopharyngeal Carcinoma is developed. In this fluorescence imaging system, the fluorescence intensity with information of detected objection is gained by an image intensifier, which makes color information of the fluorescence image eliminated and the result is a monochrome image of the fluorescence with thermally induced noise. The monochrome fluorescence image is sent to a CCD and captured by an image board, which is controlled by a computer. Image processing is carried out to improve the image quality and therefore improve the system's ability to differentiate carcinomas from normal tissue. Gaussian smoothing is implemented in order to reduce the noise. Image binarizing process is realized to obtain an optimal threshold of the image. Image pixels with grey value below this threshold are assigned as diseased and those above are normal. A pseudo color processing is then accomplished to get better visual perception and understanding of the image, greatly increasing the detail resolution of the grey image. The processed image is then displayed on the screen of the computer in real time. The real time laser induced fluorescence imaging system with the image processing methods developed is efficient for localization of the nasopharyngeal carcinoma.

Citation Download Citation

Lina Liu and Shusen Xie "Laser induced fluorescence imaging system for localization of nasopharyngeal carcinoma", Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 68262M (8 January 2008); https://doi.org/10.1117/12.755102

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KEYWORDS

Image processing

Luminescence

Image enhancement

Imaging systems

Laser induced fluorescence

Tissues

Image intensifiers

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