Full path Monte Carlo simulation of fluorescence in non-voxelized complex heterogeneous mouse model

Jean-Francois Delorme; Guobin Ma; Frederic Lesage; Frederic Leblond; Anader Benyamin-Seyar

doi:10.1117/12.760822

20 February 2008 Full path Monte Carlo simulation of fluorescence in non-voxelized complex heterogeneous mouse model

Jean-Francois Delorme, Guobin Ma, Frederic Lesage, Frederic Leblond, Anader Benyamin-Seyar

Proceedings Volume 6854, Optical Interactions with Tissue and Cells XIX; 68541M (2008) https://doi.org/10.1117/12.760822
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

In this article we propose an approach to improve the Monte Carlo simulation accuracy by implementing a full photon path integration simulation in a non-voxelized complex three-dimensional heterogeneous model. Mouse body shape, organs optical heterogeneities and fluorophore distribution are simulated by using boundary surface elements and basic analytical shapes. In addition, external and internal surface roughness and refractive index mismatch for complex angular objects are also considered and results are briefly compared with time sampled space voxelized Monte Carlo code, in order to illustrate the impact of these improvements on the simulation results.

Citation Download Citation

Jean-Francois Delorme, Guobin Ma, Frederic Lesage, Frederic Leblond, and Anader Benyamin-Seyar "Full path Monte Carlo simulation of fluorescence in non-voxelized complex heterogeneous mouse model", Proc. SPIE 6854, Optical Interactions with Tissue and Cells XIX, 68541M (20 February 2008); https://doi.org/10.1117/12.760822

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