Dynamic of gold nanoparticles labeling studied on the basis of OCT and backscattering spectra of tissues and phantoms

G. G. Akchurin; I. L. Maksimova; V. P. Rybukho; V. V. Lychagov; B. N. Khlebtsov; N. G. Khlebtsov; G. G. Akchurin Jr.; I. O. Kolbenev; V. Yu. Maksimov; O. G. Naumova; A. A. Skaptsov; G. S. Terentyuk; V. V. Tuchin

doi:10.1117/12.767641

6 February 2008 Dynamic of gold nanoparticles labeling studied on the basis of OCT and backscattering spectra of tissues and phantoms

G. G. Akchurin, I. L. Maksimova, V. P. Rybukho, V. V. Lychagov, B. N. Khlebtsov, N. G. Khlebtsov, G. G. Akchurin Jr., I. O. Kolbenev, V. Yu. Maksimov, O. G. Naumova, A. A. Skaptsov, G. S. Terentyuk, V. V. Tuchin

Author Affiliations +

Proceedings Volume 6855, Complex Dynamics and Fluctuations in Biomedical Photonics V; 68550K (2008) https://doi.org/10.1117/12.767641
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

A new interference scheme of low-coherent interferometry was considered. This interference system does not use a special supporting beam. An object is lighted up by optical field directly from source of light. Back-scattered radiation is put to correlation analysis using Michelson scanning interferometer. Such unsupported interference system has a number of advantages, e.g. conducting experiments in vivo. A comparison of spatial sensitivity of OCT and HRT tomographs resolution was made during identification of local inhomogeneity in presence of nanoshells and nanorods in bio-phantoms and bio-tissues. Plasmon-resonant gold nanoparticles can be used as a new class of contrast agents in OCT diagnostics. The theoretical part of our study was to simulate the backscattering signal related to the process of electromagnetic wave propagation through a system of discrete scattering particles with consideration the effects of different scattering multiplicity. By using the computer Monte Carlo simulations, we calculated the spectra of collimated transmission, diffuse forward and back scattering for the systems of gold spherical particles and shells.

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G. G. Akchurin, I. L. Maksimova, V. P. Rybukho, V. V. Lychagov, B. N. Khlebtsov, N. G. Khlebtsov, G. G. Akchurin Jr., I. O. Kolbenev, V. Yu. Maksimov, O. G. Naumova, A. A. Skaptsov, G. S. Terentyuk, and V. V. Tuchin "Dynamic of gold nanoparticles labeling studied on the basis of OCT and backscattering spectra of tissues and phantoms", Proc. SPIE 6855, Complex Dynamics and Fluctuations in Biomedical Photonics V, 68550K (6 February 2008); https://doi.org/10.1117/12.767641

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