Fluorescence molecular tomography using a priori photoacoustic data

Daniel Razansky; Vasilis Ntziachristos

doi:10.1117/12.764272

11 March 2008 Fluorescence molecular tomography using a priori photoacoustic data

Proceedings Volume 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics; 685617 (2008) https://doi.org/10.1117/12.764272
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

We present the first hybrid photoacoutic fluorescence molecular tomography system, capable of three-dimensional imaging of both fluorochrome and chromophore distributions in highly scattering and absorbing tissues. Quantitative three-dimensional maps of optical absorption coefficient are acquired using photoacoustic tomography. The reconstructed absorption data is fed into the Fluorescence Molecular Tomography inversion scheme in order to improve its accuracy and quatification capabilities in the presence of strong and distributed absorbers that are expected to bias stand-alone fluorescence reconstructions. At all, having both techniques in one hybrid modality yields a system that combines high molecular specificity and targeting flexibility of fluorescent imaging and high spatial resolution functional information obtained via photo-acoustic images.

Citation Download Citation

Daniel Razansky and Vasilis Ntziachristos "Fluorescence molecular tomography using a priori photoacoustic data", Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 685617 (11 March 2008); https://doi.org/10.1117/12.764272

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KEYWORDS

Absorption

Acquisition tracking and pointing

Luminescence

Tissues

Tissue optics

Tomography

Imaging systems

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