Optofluidic microscope: a complete on-chip imaging device

Xiquan Cui; Xin Heng; Changhuei Yang

doi:10.1117/12.764957

29 February 2008 Optofluidic microscope: a complete on-chip imaging device

Xiquan Cui, Xin Heng, Changhuei Yang

Proceedings Volume 6859, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VI; 68590Y (2008) https://doi.org/10.1117/12.764957
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

This paper reports a complete on-chip high resolution lensless imaging device based on the optofluidic microscopy method, which can form a vital optical microscopy component in a wide range of lab-on-a-chip systems. This imaging device does not use any lens elements and yet is capable of resolution comparable to that of a conventional microscope with a 20× objective. We demonstrate the use of the device for Caenorhabditis elegans and microsphere imaging at a resolution of ~ 1 μm with an imaging time of ~2 sec. The fabrication of this on-chip imaging device is fully compatible with existing semiconductor and microfluidic technologies, so the device can be massively fabricated and integrated into microsystems to form compact and low-cost total analysis systems for biological and colloidal studies.

Citation Download Citation

Xiquan Cui, Xin Heng, and Changhuei Yang "Optofluidic microscope: a complete on-chip imaging device", Proc. SPIE 6859, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VI, 68590Y (29 February 2008); https://doi.org/10.1117/12.764957

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