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21 February 2008 Influence of gold nanoparticles on platelets functional activity in vitro
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Now in the leading biomedical centers of the world approved new technology of laser photothermal destruction of cancer cells using plasmon gold nanoparticles. Investigations of influence of gold nanoparticles on white rat platelets aggregative activity in vitro have been made. Platelet aggregation was investigated in platelet rich plasma (PRP) with help of laser analyzer 230 LA <<BIOLA>> (Russia). Aggregation inductor was ADP solution in terminal concentration 2.5 micromole (<<Reanal>>, Russia). Gold nanoshells soluted in salt solution were used for experiments. Samples of PRP were incubated with 50 or 100 μl gold nanoshells solution in 5 minute, after that we made definition ADP induced platelet aggregation. We found out increase platelet function activity after incubation with nanoparticles solution which shown in maximum ADP-induced aggregation degree increase. Increase platelet function activity during intravenous nanoshells injection can be cause of thrombosis on patients. That's why before clinical application of cancer cell destruction based on laser photothermal used with plasmon gold nanoparticles careful investigations of thrombosis process and detail analyze of physiological blood parameters are very necessary.
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Garif G. Akchurin, George G. Akchurin, Alexey N. Ivanov, Vyacheslav F. Kirichuk, George S. Terentyuk, Boris N. Khlebtsov, and Nikolay G. Khlebtsov "Influence of gold nanoparticles on platelets functional activity in vitro", Proc. SPIE 6869, Plasmonics in Biology and Medicine V, 68690V (21 February 2008);

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