Developments of the in-check platform for diagnostic applications

Michele Palmieri; Enrico Alessi; Sabrina Conoci; Mauro Marchi; Gaetano Panvini

doi:10.1117/12.778331

12 February 2008 Developments of the in-check platform for diagnostic applications

Michele Palmieri, Enrico Alessi, Sabrina Conoci, Mauro Marchi, Gaetano Panvini

Proceedings Volume 6886, Microfluidics, BioMEMS, and Medical Microsystems VI; 688602 (2008) https://doi.org/10.1117/12.778331
Event: MOEMS-MEMS 2008 Micro and Nanofabrication, 2008, San Jose, California, United States

Abstract

In-Check is STMicroelectronics proprietary platform for molecular diagnostics. In-Check lays its foundations on the monolithic integration of microelectronics and micromachining technology MEMS, with microfluidic and optical features, bio-chemical surface functionalization and molecular biology. It comprises a core lab-on-chip device, control and reading instrumentation, a complete suite of software modules, and application protocols. Leveraging on such capabilities, In-Check enables fast, highly sensitive and specific, multi-analytical capability of nucleic acid analysis. The platform provides a unique combination of nucleic acid amplification, by polymerase-chain-reaction and target identification and typing by DNA microarray. These integrated biological functionalities together with top quality standard and process control are key features for a platform to be accepted by the highly demanding modern medical diagnostic. This paper describes recent developments of In-Check and some core biological characterizations.

Citation Download Citation

Michele Palmieri, Enrico Alessi, Sabrina Conoci, Mauro Marchi, and Gaetano Panvini "Developments of the in-check platform for diagnostic applications", Proc. SPIE 6886, Microfluidics, BioMEMS, and Medical Microsystems VI, 688602 (12 February 2008); https://doi.org/10.1117/12.778331

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