Surface enhanced Raman spectroscopy on chip

Jorg Hubner; Thomas Anhøj; Sarah Pedersen; Dan A. Zauner; Anders M. Jorgensen; Gabriella Blagoi; Ivan Talian; Ole Hansen

doi:10.1117/12.761076

28 February 2008 Surface enhanced Raman spectroscopy on chip

Jorg Hubner, Thomas Anhøj, Sarah Pedersen, Dan A. Zauner, Anders M. Jorgensen, Gabriella Blagoi, Ivan Talian, Ole Hansen

Author Affiliations +

Proceedings Volume 6896, Integrated Optics: Devices, Materials, and Technologies XII; 689614 (2008) https://doi.org/10.1117/12.761076
Event: Integrated Optoelectronic Devices 2008, 2008, San Jose, California, United States

Abstract

In this paper we report on an integrated spectrometer device, fabricated in epoxy resist (SU-8) on silicon, designed for Raman spectroscopy and direct coupling to a CCD element. Furthermore a nanostructured surface is prepared on a gold coated silicon chip to enhance the Raman signal. We show examples of low resolution Surface Enhanced Raman Spectra (SERS) recorded with this chip and provide an outlook on the future possibilities. Traditional optical detection in Lab-on-Chip devices often requires sample pretreatment including chemical reactions in order to identify and detect a certain substance (e.g. attachment of a fluorescent marker). The basic idea in bringing Raman spectroscopy to the chip is to avoid these chemical reactions and directly enable identification of the substance by its Raman spectrum. Two different methods were used to prepare the nanostructured surfaces. The first method is based on an aqueous suspension of gold nanoparticles and polystyrene beads deposited on a gold surface. The suspension was dried and the polystyrene beads were removed using an appropriate solvent (methane dichloride). The second approach includes gold coated random silicon nanostructures so-called "black silicon". The surfaces were characterized using a commercial Raman spectrometer and the enhancement factor was found to be strongly dependant on the concentration on the sample surface. The surface was impregnated with a droplet (10 μl, 100 μM) of Rhodamin 6G and Nileblue respectively. Using the on-chip spectrometer we have recorded surface enhanced Raman spectra of Nileblue and Rhodamin 6G respectively. The results show that these systems are suitable for low cost extremely compact Raman sensors with possible applications reaching from process monitoring to homeland security and point of care devices.

Citation Download Citation

Jorg Hubner, Thomas Anhøj, Sarah Pedersen, Dan A. Zauner, Anders M. Jorgensen, Gabriella Blagoi, Ivan Talian, and Ole Hansen "Surface enhanced Raman spectroscopy on chip", Proc. SPIE 6896, Integrated Optics: Devices, Materials, and Technologies XII, 689614 (28 February 2008); https://doi.org/10.1117/12.761076

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