Contrast-enhanced dual-energy subtraction imaging using electronic spectrum-splitting and multi-prism x-ray lenses

Erik Fredenberg; Björn Cederström; Mats Lundqvist; Carolina Ribbing; Magnus Åslund; Felix Diekmann; Robert Nishikawa; Mats Danielsson

doi:10.1117/12.770501

18 March 2008 Contrast-enhanced dual-energy subtraction imaging using electronic spectrum-splitting and multi-prism x-ray lenses

Erik Fredenberg, Björn Cederström, Mats Lundqvist, Carolina Ribbing, Magnus Åslund, Felix Diekmann, Robert Nishikawa, Mats Danielsson

Author Affiliations +

Proceedings Volume 6913, Medical Imaging 2008: Physics of Medical Imaging; 691310 (2008) https://doi.org/10.1117/12.770501
Event: Medical Imaging, 2008, San Diego, California, United States

Abstract

Dual-energy subtraction imaging (DES) is a method to improve the detectability of contrast agents over a lumpy background. Two images, acquired at x-ray energies above and below an absorption edge of the agent material, are logarithmically subtracted, resulting in suppression of the signal from the tissue background and a relative enhancement of the signal from the agent. Although promising, DES is still not widely used in clinical practice. One reason may be the need for two distinctly separated x-ray spectra that are still close to the absorption edge, realized through dual exposures which may introduce motion unsharpness. In this study, electronic spectrum-splitting with a silicon-strip detector is theoretically and experimentally investigated for a mammography model with iodinated contrast agent. Comparisons are made to absorption imaging and a near-ideal detector using a signal-to-noise ratio that includes both statistical and structural noise. Similar to previous studies, heavy absorption filtration was needed to narrow the spectra at the expense of a large reduction in x-ray flux. Therefore, potential improvements using a chromatic multi-prism x-ray lens (MPL) for filtering were evaluated theoretically. The MPL offers a narrow tunable spectrum, and we show that the image quality can be improved compared to conventional filtering methods.

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Erik Fredenberg, Björn Cederström, Mats Lundqvist, Carolina Ribbing, Magnus Åslund, Felix Diekmann, Robert Nishikawa, and Mats Danielsson "Contrast-enhanced dual-energy subtraction imaging using electronic spectrum-splitting and multi-prism x-ray lenses", Proc. SPIE 6913, Medical Imaging 2008: Physics of Medical Imaging, 691310 (18 March 2008); https://doi.org/10.1117/12.770501

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