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19 March 2008 Microcalcification detectability in tomosynthesis
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Microcalcifications (MCs) are an important early sign of breast cancer. In conventional mammography, MC detectability is limited primarily due to quantum noise. In tomosynthesis, a dose comparable to that delivered in one projection mammogram is divided across a number of projection views (typically ranging between 10 and 30). This potentially will reduce the detectability of MCs, if detector noise is not very low. The purpose of this study is to explore the relationship between MC detectability in the projection views and in the reconstructed image. The effect of angular range and number of angles on detectability will also be evaluated for an ideal detector. Microcalcification detectability is shown to be greater in the sinogram than in the reconstructed images. Further, the detectability is reduced when the MC is located far from the center of the breast. Also, the detectability in the projection images is dependent on the projection angle.
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Beverly A. Lau, Ingrid S. Reiser, and Robert M. Nishikawa "Microcalcification detectability in tomosynthesis", Proc. SPIE 6913, Medical Imaging 2008: Physics of Medical Imaging, 69134L (19 March 2008);

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