Histopathology and MR image fusion of the prostate

Hyun Hee Jo; Julip Jung; Yujin Jang; Helen Hong; Hak Jong Lee

doi:10.1117/12.771380

11 March 2008 Histopathology and MR image fusion of the prostate

Hyun Hee Jo, Julip Jung, Yujin Jang, Helen Hong, Hak Jong Lee

Proceedings Volume 6914, Medical Imaging 2008: Image Processing; 691430 (2008) https://doi.org/10.1117/12.771380
Event: Medical Imaging, 2008, San Diego, California, United States

Abstract

We propose a method for combining histopathology image with MR image of the prostate by using image correction and nonrigid registration. Our method consists of four steps. First, two or four tissue sections of the prostate in histopathology image are combined to produce a single prostate image by stitching. Second, the intensity of prostate bleeding area on T2-weighted MR image is substituted for that on T1-weighted MR image. Our intensity correction prevents a mistake which a prostate bleeding is considered as a tumor on T2-weighted MR image. Third, rough and fine registration is performed to find the best match for pixel overlap between histopathology and MR images. Then the result of rigid registration is deformed by the TPS warping. Finally, aligned images are visualized by the intensity intermixing. Experimental results show that the prostate tumor lesion can be properly located and clearly visualized within MR images for tissue characterization comparison.

Citation Download Citation

Hyun Hee Jo, Julip Jung, Yujin Jang, Helen Hong, and Hak Jong Lee "Histopathology and MR image fusion of the prostate", Proc. SPIE 6914, Medical Imaging 2008: Image Processing, 691430 (11 March 2008); https://doi.org/10.1117/12.771380

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available