A wide range of pulmonary diseases, including common ones such as COPD, affect the airways. If the dimensions
of airway can be measured with high confidence, the clinicians will be able to better diagnose diseases as well
as monitor progression and response to treatment. In this paper, we introduce a method to assess the airway
dimensions from CT scans, including the airway segments that are not oriented axially. First, the airway lumen
is segmented and skeletonized, and subsequently each airway segment is identified. We then represent each
airway segment using a segment-centric generalized cylinder model and assess airway lumen diameter (LD)
and wall thickness (WT) for each segment by determining inner and outer wall boundaries. The method was
evaluated on 14 healthy patients from a Weill Cornell database who had two scans within a 2 month interval.
The corresponding airway segments were located in two scans and measured using the automated method. The
total number of segments identified in both scans was 131. When 131 segments were considered altogether, the
average absolute change over two scans was 0.31 mm for LD and 0.12 mm for WT, with 95% limits of agreement
of [-0.85, 0.83] for LD and [-0.32, 0.26] for WT. The results were also analyzed on per-patient basis, and the
average absolute change was 0.19 mm for LD and 0.05 mm for WT. 95% limits of agreement for per-patient
changes were [-0.57, 0.47] for LD and [-0.16, 0.10] for WT.